FORMULASI SEDIAAN GEL MINYAK ATSIRI TANAMAN NILAM (POGOSTEMON CABLIN BENTH) SEBAGAI ANTISEPTIK TANGAN (HAND SANITIZER)
نویسندگان
چکیده
Indonesia termasuk salah satu negara penghasil minyak atsiri terbesar di dunia, dan ini juga merupakan komoditi yang menghasilkan devisa Negara. Penghasil mempunyai prospek cukup tinggi adalah tanaman nilam (Pogostemon cablin Benth) berasal dari provinsi Aceh. Nilam Aceh terbaik kedua dunia dapat dengan kandungan Patchouli Alcohol (PA) atas 30%. Komposisi hand sanitizer beredar pasaran saat masih menggunakan alkohol sebagai bahan aktifnya dirasa kurang aman terhadap kesehatan, karena melarutkan lapisan lemak pada kulit berfungsi pelindung infeksi mikroorganisme. Pada pemakaian berulang menyebabkan kekeringan serta iritasi kulit, oleh sebab itu perlu diteliti lain dimanfaatkan antibakteri. Salah alami diharapkan alternatif potensial untuk mengganti penggunaan zat aktif nilam. Penelitian bertujuan membuat formulasi menguji efektivitas antiseptik tangan sediaan gel 5 variasi volume, yakni 0; 1; 3; 5; 7 mL. Pengujian dilakukan kelima meliputi sifat fisik yaitu, pengujian organoleptik, pH, daya sebar, viskositas, aktivitas bakteri. Formulasi baik diperoleh yaitu formula A2K1 (minyak 1 mL, karbopol 940 gr, propilen glikol TEA gliserin 10 metil paraben 0,18 aquadest 100 mL), memiliki bentuk sesuai menghambat pertumbuhan bakteri staphylococcus aureus diameter zona hambat sebesar 6,8 mm, hasil homogen, pH 8,4 mendekati sebar menunjukkan konsistensi semisolid sangat nyaman dalam sekitar 4 – 8 cm.
منابع مشابه
Identification of two chemotypes of Pogostemon cablin (Blanco) Benth. through DNA barcodes.
Pogostemon cablin (Blanco) Benth. is an important medicinal plant in Traditional Chinese Medicine (TCM). Because of differences in the chemical composition, this species has been classified into two major chemotypes, i. e. the patchouliol-type and the pogostone-type; however, no quick and effective method is presently available for the precise identification of these two chemotypes. DNA barcodi...
متن کاملPolyphenolic glycosides isolated from Pogostemon cablin (Blanco) Benth. as novel influenza neuraminidase inhibitors
BACKGROUND Influenza is historically an ancient disease that causes annual epidemics and, at irregular intervals, pandemics. At present, the first-line drugs (oseltamivir and zanamivir) don't seem to be optimistic due to the spontaneously arising and spreading of oseltamivir resistance among influenza virus. Pogostemon cablin (Blanco) Benth. (P. cablin) is an important traditional Chinese medic...
متن کاملCharacterization and Antimicrobial Activity of Patchouli Essential Oil Extracted From Pogostemon cablin [Blanco] Benth. [lamiaceae]
Article history: Received 25 March 2014 Received in revised form 20 April 2014 Accepted 15 May 2014 Available online 10 June 2014
متن کاملT cell inhibition by pogostone from Pogostemon cablin (Blanco) Benth: In vitro and in vivo immunosuppressive analysis
Various plant-derived compounds exhibit immunosuppressive activity in pre‑clinical investigations, suggesting that they may serve as natural alternatives for the prevention of inflammatory disorders and autoimmune diseases. The aim of the current study was to explore the immunosuppressive potential of pogostone (PO) derived from Pogostemon cablin (Blanco) Benth. Carboxyfluorescein diacetate suc...
متن کاملSerological and Molecular Studies of a Novel Virus Isolate Causing Yellow Mosaic of Patchouli [Pogostemon cablin (Blanco) Benth]
Here we have identified and characterized a devastating virus capable of inducing yellow mosaic on the leaves of Patchouli [Pogostemon cablin (Blanco) Benth]. The diagnostic tools used were host range, transmission studies, cytopathology, electron microscopy, serology and partial coat protein (CP) gene sequencing. Evidence from biological, serological and sequence data suggested that the causal...
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ژورنال
عنوان ژورنال: Jurnal Teknologi Kimia UNIMAL
سال: 2021
ISSN: ['2303-3991', '2580-5436']
DOI: https://doi.org/10.29103/jtku.v10i1.4179